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Tsuji–Trost Allylic Alkylation with Ketone Enolates
Author(s) -
Braun Manfred,
Meier Thorsten
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602169
Subject(s) - tsuji–trost reaction , carbanion , nucleophile , alkylation , ketone , chemistry , stereoselectivity , palladium , catalysis , organic chemistry
The traditional restriction of the palladium‐catalyzed allylation to stabilized carbanions has been overcome. Recent studies reveal that preformed “hard” enolates can serve as nucleophiles, and routes to novel stereoselective variants of the Tsuji–Trost method have thus been opened.