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Microreactor Synthesis of β‐Peptides
Author(s) -
Flögel Oliver,
Codée Jeroen D. C.,
Seebach Dieter,
Seeberger Peter H.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602167
Subject(s) - microreactor , chemistry , combinatorial chemistry , biochemistry , catalysis
Taming the insoluble : The reaction parameters of a β‐peptide synthesis were optimized using only small amounts of reagents in a silicon microreactor (see picture). The use of unusually high temperatures (up to 120 °C) reduces the reaction times. The insertion of a fluorous benzyl protecting group enhances the efficiency of the synthesis.