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Glycosidation Promoted by a Reusable Solid Superacid in Supercritical Carbon Dioxide
Author(s) -
Li XueBing,
Ogawa Masato,
Monden Toshiki,
Maeda Takahiro,
Yamashita Eri,
Naka Mariko,
Matsuda Masao,
Hinou Hiroshi,
Nishimura ShinIchiro
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602161
Subject(s) - glycoconjugate , chemistry , supercritical fluid , reagent , supercritical carbon dioxide , organic chemistry , combinatorial chemistry , biochemistry
Superduper : A practical and cleaner synthetic protocol for various glycosides was established by means of a recyclable solid superacid promoter in supercritical carbon dioxide (scCO 2 ). Anomeric mixtures composed of α‐ and β‐isomers were successfully separated by employing supercritical fluid chromatography (SFC) with scCO 2 and methanol. L=leaving group, P=protecting group, ROH= sphingosine, sugar, etc.