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Taming a Functional Group: Creating Air‐Stable, Chiral Primary Phosphanes
Author(s) -
Hiney Rachel M.,
Higham Lee J.,
MüllerBunz Helge,
Gilheany Declan G.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602143
Subject(s) - synthon , enantiopure drug , ring (chemistry) , primary (astronomy) , aryl , group (periodic table) , ligand (biochemistry) , chemistry , class (philosophy) , stability (learning theory) , combinatorial chemistry , stereochemistry , materials science , organic chemistry , computer science , physics , catalysis , enantioselective synthesis , receptor , astronomy , artificial intelligence , machine learning , biochemistry , alkyl
No rings of fire! Enantiopure primary phosphanes have been developed which are remarkably stable to air oxidation in both solid and solution states (see example). This new class of stable ligand synthon appears to owe its stability to conjugation in their aryl backbones with the extended π ring system. Even one extra ring is good enough.