Premium
A Photoswitchable Miniprotein Based on the Sequence of Avian Pancreatic Polypeptide
Author(s) -
Jurt Simon,
Aemissegger Andreas,
Güntert Peter,
Zerbe Oliver,
Hilvert Donald
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602084
Subject(s) - linker , azobenzene , sequence (biology) , computer science , peptide , transformation (genetics) , chemistry , simple (philosophy) , computational biology , combinatorial chemistry , crystallography , biochemistry , biology , molecule , organic chemistry , programming language , gene , philosophy , epistemology
Flip a switch : A peptide capable of adopting different conformations is constructed upon insertion of an azobenzene linker into the polypeptide backbone. A simple transformation (irradiation or heating) can be used to switch from one form to the other.