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Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis
Author(s) -
Nakao Yoichi,
Yoshida Satoru,
Matsunaga Shigeki,
Shindoh Nobuaki,
Terada Yoh,
Nagai Koji,
Yamashita Jun K.,
Ganesan A.,
van Soest Rob W. M.,
Fusetani Nobuhiro
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602047
Subject(s) - histone deacetylase , inhibitory postsynaptic potential , sponge , chemistry , ic50 , acetylation , histone , stereochemistry , biochemistry , botany , biology , in vitro , neuroscience , gene
A zoom in on azumamides (1) : Azumamides A–E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC 50 values of 0.045–1.3 μg mL −1 . Their structures were determined on the basis of spectroscopic analysis and chemical degradation.