Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge  Mycale izuensis | Zendy

Nakao Yoichi | Zendy; Yoshida Satoru | Zendy; Matsunaga Shigeki | Zendy; Shindoh Nobuaki | Zendy; Terada Yoh | Zendy; Nagai Koji | Zendy; Yamashita Jun K. | Zendy; Ganesan A. | Zendy; van Soest Rob W. M. | Zendy; Fusetani Nobuhiro | Zendy

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Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis

Author(s) -

Nakao Yoichi,

Yoshida Satoru,

Matsunaga Shigeki,

Shindoh Nobuaki,

Terada Yoh,

Nagai Koji,

Yamashita Jun K.,

Ganesan A.,

van Soest Rob W. M.,

Fusetani Nobuhiro

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200602047

Subject(s) - histone deacetylase , inhibitory postsynaptic potential , sponge , chemistry , ic50 , acetylation , histone , stereochemistry , biochemistry , botany , biology , in vitro , neuroscience , gene

A zoom in on azumamides (1) : Azumamides A–E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC 50 values of 0.045–1.3 μg mL −1 . Their structures were determined on the basis of spectroscopic analysis and chemical degradation.

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