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Self‐Assembly of Fibers and Fibrils
Author(s) -
Binder Wolfgang H.,
Smrzka Oskar W.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200602001
Subject(s) - fibril , protein folding , fiber , kinetics , protein aggregation , biophysics , folding (dsp implementation) , chemistry , nanotechnology , materials science , biochemistry , biology , physics , organic chemistry , engineering , quantum mechanics , electrical engineering
Too much fiber? Protein fibers play an important role in cellular processes, but are also involved in protein‐folding diseases, such as Alzheimer's disease. Modern screening and validation models allow the investigation of the aggregation and deaggregation kinetics of protein fibers (see scheme). These studies can serve as a starting point for the development of new therapeutic strategies.