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Enantioselective Total Synthesis and Structure Determination of the Antiherpetic Anthrapyran Antibiotic AH‐1763 IIa
Author(s) -
Tietze Lutz F.,
Gericke Kersten M.,
Singidi Ramakrishna Reddy
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601992
Subject(s) - enantioselective synthesis , diastereomer , antibiotics , stereochemistry , chemistry , natural product , organic chemistry , biochemistry , catalysis
The antiherpetic anthrapyran antibiotic (14 S ,16 R )‐AH‐1763 IIa (see right‐hand structure) and its (14 R ,16 R ) diastereomer have been prepared in enantioselective total syntheses. The relative and absolute stereochemistry of the natural product was established as (14 R ,16 S ), and a general high‐yielding, selective approach to anthrapyran antibiotics was developed.