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meta ‐Directing Cobalt‐Catalyzed Diels–Alder Reactions
Author(s) -
Hilt Gerhard,
Janikowski Judith,
Hess Wilfried
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601974
Subject(s) - regioselectivity , cobalt , catalysis , chemistry , diels–alder reaction , diimine , combinatorial chemistry , organic chemistry
Overcoming the ortho / para rule? The regioselectivity of Diels–Alder reactions with neutral electron demand between 1,3‐dienes with alkynes can be controlled by simple cobalt diimine complexes so that the meta ‐substituted cycloadducts are generated in good yields and excellent regioselectivity (see scheme; DDQ=2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone).