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Pd‐Catalyzed α‐Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides: A Synergistic Effect of Two Metal Fluorides as Additives
Author(s) -
Su Weiping,
Raders Steven,
Verkade John G.,
Liao Xuebin,
Hartwig John F.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601887
Subject(s) - enol , silylation , aryl , chemistry , trimethylsilyl , catalysis , fluoride , palladium , metal , organic chemistry , combinatorial chemistry , inorganic chemistry , alkyl
The long‐sought‐after palladium‐catalyzed coupling of silyl enol ethers, both cyclic and acyclic, with a wide range of aryl bromides and chlorides to form α‐aryl ketones is realized. The key to effective activation of the silicon enolate was the use of two metal fluoride additives, which operate in a synergistic fashion.