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Structure Identification of Precatalytic Copper Phosphoramidite Complexes in Solution
Author(s) -
Zhang Hongxia,
Gschwind Ruth M.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601880
Subject(s) - phosphoramidite , copper , chemistry , tetrahedron , mass spectrometry , catalysis , nuclear magnetic resonance spectroscopy , enantioselective synthesis , stereoselectivity , ligand (biochemistry) , combinatorial chemistry , crystallography , stereochemistry , organic chemistry , dna , biochemistry , receptor , chromatography , oligonucleotide
1+1 is more than 2 : A binuclear copper phosphoramidite precatalyst with mixed trigonal/tetrahedral coordination environments (see picture) is proposed based on NMR spectroscopy, mass spectrometry, and elemental analysis. The precatalyst represents a new structural motif for stereoselective copper catalysts and explains ligand acceleration and salt sensitivity in highly enantioselective 1,4‐additions to enones.