Metal–Organic Frameworks as Efficient Materials for Drug Delivery | Zendy

Horcajada Patricia | Zendy; Serre Christian | Zendy; ValletRegí María | Zendy; Sebban Muriel | Zendy; Taulelle Francis | Zendy; Férey Gérard | Zendy

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Metal–Organic Frameworks as Efficient Materials for Drug Delivery

Author(s) -

Horcajada Patricia,

Serre Christian,

ValletRegí María,

Sebban Muriel,

Taulelle Francis,

Férey Gérard

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601878

Subject(s) - ibuprofen , drug delivery , metal organic framework , drug , porosity , substrate (aquarium) , nanotechnology , materials science , computer science , chemical engineering , chemistry , engineering , medicine , pharmacology , organic chemistry , composite material , geology , oceanography , adsorption

Fill 'em up : The metal carboxylates MIL‐100 and MIL‐101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug‐delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL‐101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL‐100) and 6 days (MIL‐101).

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