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Metal–Organic Frameworks as Efficient Materials for Drug Delivery
Author(s) -
Horcajada Patricia,
Serre Christian,
ValletRegí María,
Sebban Muriel,
Taulelle Francis,
Férey Gérard
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601878
Subject(s) - ibuprofen , drug delivery , metal organic framework , drug , porosity , substrate (aquarium) , nanotechnology , materials science , computer science , chemical engineering , chemistry , engineering , medicine , pharmacology , organic chemistry , composite material , geology , oceanography , adsorption
Fill 'em up : The metal carboxylates MIL‐100 and MIL‐101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug‐delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL‐101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL‐100) and 6 days (MIL‐101).