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Cascade Reactions in Total Synthesis
Author(s) -
Nicolaou K. C.,
Edmonds David J.,
Bulger Paul G.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601872
Subject(s) - cascade , novelty , elegance , total synthesis , computer science , biochemical engineering , task (project management) , chemistry , engineering , systems engineering , organic chemistry , epistemology , psychology , philosophy , social psychology , chromatography
The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.