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Configurationally Stable Molecular Propellers: First Resolution of Residual Enantiomers
Author(s) -
Benincori Tiziana,
Celentano Giuseppe,
Pilati Tullio,
Ponti Alessandro,
Rizzo Simona,
Sannicolò Francesco
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601869
Subject(s) - enantiopure drug , enantiomer , phosphine , residual , chemistry , aryl , resolution (logic) , combinatorial chemistry , stereochemistry , computer science , organic chemistry , enantioselective synthesis , algorithm , programming language , alkyl , catalysis
Fixing the propeller : There is general consensus that phosphine oxides and phosphines carrying three identical aryl groups are operationally achiral compounds. Herein it is shown that suitably tailored triarylphosphine oxides give rise to configurationally stable residual enantiomers, which were isolated in an enantiopure state.