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Total Synthesis of Marinomycins A–C
Author(s) -
Nicolaou K. C.,
Nold Andrea L.,
Milburn Robert R.,
Schindler Corinna S.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601867
Subject(s) - forge , ring (chemistry) , content (measure theory) , chemistry , oceanography , computer science , geology , engineering , mathematics , organic chemistry , mechanical engineering , forging , mathematical analysis
Ocean's three : Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge their remarkable polyunsaturated 44‐membered‐ring systems (see picture).