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Gold(III)‐ and Platinum(II)‐Catalyzed Domino Reaction Consisting of Heterocyclization and 1,2‐Migration: Efficient Synthesis of Highly Substituted 3(2 H )‐Furanones
Author(s) -
Kirsch Stefan F.,
Binder Jörg T.,
Liébert Clémence,
Menz Helge
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601836
Subject(s) - oxonium ion , domino , chemistry , stereospecificity , alkyne , catalysis , cascade reaction , alkyl , medicinal chemistry , combinatorial chemistry , ion , organic chemistry
PtCl 2 ‐catalyzed alkyne activation initiates a domino reaction, in which a heterocyclization is followed by a 1,2‐alkyl migration, for the construction of a variety of substituted 3(2 H )‐furanones. This stereospecific reaction is proposed to proceed through an oxonium ion intermediate (see scheme).