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Ruthenium‐Induced Allylcarbamate Cleavage in Living Cells
Author(s) -
Streu Craig,
Meggers Eric
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601752
Subject(s) - ruthenium , cleavage (geology) , chemistry , catalysis , combinatorial chemistry , computer science , world wide web , biochemistry , biology , paleontology , fracture (geology)
Easy going : A ruthenium‐catalyzed release of amines from their respective allylcarbamates is disclosed and is a step towards the design of catalysts as tools for cellular biology. The reaction tolerates the combination of water, air, and thiols and can be performed inside living mammalian cells. Cp*=pentamethylcyclopentadienyl, cod=1,5‐cyclooctadiene.
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