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Sequence‐Specific Nucleic Acid Damage Induced by Peptide Nucleic Acid Conjugates That Can Be Enzyme‐Activated
Author(s) -
Simon Philippe,
Décout JeanLuc,
Fontecave Marc
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601681
Subject(s) - peptide nucleic acid , nucleic acid , oligonucleotide , moiety , conjugate , flavin group , peptide , chemistry , biochemistry , sequence (biology) , enzyme , molecular beacon , oxidoreductase , stereochemistry , combinatorial chemistry , dna , mathematical analysis , mathematics
Recruitment drive : A 12 mer peptide nucleic acid(PNA)–flavin conjugate is prepared. When the PNA moiety is hybridized to its complementary sequence in a 25 mer oligo‐2′‐deoxyribonucleotide, the flavin moiety can recruit an NADPH:flavin oxidoreductase. This complex allows the activation of molecular oxygen in the presence of NADH and the selective oxidation of the oligonucleotide target (see scheme).