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Distal Charge Transport in Peptides
Author(s) -
Schlag Edward W.,
Sheu ShehYi,
Yang DahYen,
Selzle Heinrich L.,
Lin Sheng Hsien
Publication year - 2007
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601623
Subject(s) - bifunctional , reactivity (psychology) , kinetics , chemical physics , charge (physics) , chemistry , peptide , molecular dynamics , biophysics , nanotechnology , computational chemistry , materials science , physics , organic chemistry , biochemistry , catalysis , biology , medicine , alternative medicine , pathology , quantum mechanics
Biological systems often transport charges and reactive processes over substantial distances. Traditional models of chemical kinetics generally do not describe such extreme distal processes. In this Review, an atomistic model for a distal transport of information, which was specifically developed for peptides, is considered. Chemical reactivity is taken as the result of distal effects based on two‐step bifunctional kinetics involving unique, very rapid motional properties of peptides in the subpicosecond regime. The bifunctional model suggests highly efficient transport of charge and reactivity in an isolated peptide over a substantial distance; conversely, a very low efficiency in a water environment was found. The model suggests ultrafast transport of charge and reactivity over substantial molecular distances in a peptide environment. Many such domains can be active in a protein.