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Glycomimetic Cyclic Peptides Stimulate Neurite Outgrowth
Author(s) -
Bächle Dirk,
Loers Gabriele,
Guthöhrlein Eckhart W.,
Schachner Melitta,
Sewald Norbert
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601579
Subject(s) - neurite , cyclic peptide , chemistry , stereochemistry , mimicry , side chain , biochemistry , oligosaccharide , amino acid , peptide , biology , in vitro , organic chemistry , ecology , polymer
Alternative mimetics : Short cyclic hexapeptides (see picture; blue N, red O, white H, gray C) can be effective for oligosaccharide mimicry. The individual contributions of cyclization, amino acid stereochemistry, turn position, and side‐chain functionality to the glycomimetic properties of the peptides were identified. Two peptides proved to be high‐affinity ligands for the 412 antibody and also showed enhanced functional activity as HNK‐1 mimetics.