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Substituted Allyl Diphenylphosphine Oxides as Radical Allylating Agents
Author(s) -
Ouvry Gilles,
QuicletSire Béatrice,
Zard Samir Z.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601556
Subject(s) - diphenylphosphine , diphenylphosphine oxide , reagent , chemistry , content (measure theory) , scheme (mathematics) , medicinal chemistry , combinatorial chemistry , organic chemistry , phosphine , catalysis , mathematics , mathematical analysis
Radically useful : The radical addition of dithiocarbonates to branched allyl diphenylphosphine oxides can be followed by elimination of a diphenylphosphinoyl radical, thereby giving rise to allylated products (see scheme; Phth=phthalimido). Highly functionalized structures can thus be rapidly assembled under mild conditions and from cheap and readily available substrates and reagents.