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Reactions in Droplets in Microfluidic Channels
Author(s) -
Song Helen,
Chen Delai L.,
Ismagilov Rustem F.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601554
Subject(s) - microfluidics , nanotechnology , miniaturization , reagent , compartmentalization (fire protection) , mixing (physics) , chemistry , materials science , physics , enzyme , biochemistry , organic chemistry , quantum mechanics
Fundamental and applied research in chemistry and biology benefits from opportunities provided by droplet‐based microfluidic systems. These systems enable the miniaturization of reactions by compartmentalizing reactions in droplets of femoliter to microliter volumes. Compartmentalization in droplets provides rapid mixing of reagents, control of the timing of reactions on timescales from milliseconds to months, control of interfacial properties, and the ability to synthesize and transport solid reagents and products. Droplet‐based microfluidics can help to enhance and accelerate chemical and biochemical screening, protein crystallization, enzymatic kinetics, and assays. Moreover, the control provided by droplets in microfluidic devices can lead to new scientific methods and insights.