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Rh‐Catalyzed Asymmetric Hydrogenation of α‐Aryl Imino Esters: An Efficient Enantioselective Synthesis of Aryl Glycine Derivatives
Author(s) -
Shang Gao,
Yang Qin,
Zhang Xumu
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601540
Subject(s) - enantioselective synthesis , aryl , glycine , catalysis , chemistry , asymmetric hydrogenation , diene , organic chemistry , combinatorial chemistry , amino acid , biochemistry , alkyl , natural rubber
A highly enantioselective synthesis of aryl glycine derivatives from asymmetric hydrogenation was achieved by subjecting N ‐PMP‐protected α‐aryl imino esters to hydrogenation under Rh–bisphosphine catalysis (see scheme; PMP= para ‐methoxyphenyl, cod=cycloocta‐1,5‐diene). The PMP group could be easily removed for the preparation of enantiomerically pure aryl glycine derivatives.