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MicroRNAs—Future Drug Targets?
Author(s) -
Arenz Christoph
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601537
Subject(s) - microrna , gene silencing , computational biology , biology , small rna , rna induced silencing complex , rna , rna silencing , function (biology) , rna interference , microbiology and biotechnology , cancer research , non coding rna , gene , genetics
Big things come in small packages : MicroRNAs (miRNAs) are small regulatory RNA molecules in eukaryotes. Altered miRNA expression patterns can be used as a diagnostic tool, for example, in patients with chronic lymphatic leukemia. Also, the inhibition of miRNA function in vivo has been recently achieved by using “antagomirs”—antisense cholesterol conjugates (see scheme; miRNP=miRNA–protein complex, RISC=RNA‐induced silencing complex).