MicroRNAs—Future Drug Targets? | Zendy

Arenz Christoph | Zendy

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MicroRNAs—Future Drug Targets?

Author(s) -

Arenz Christoph

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601537

Subject(s) - microrna , gene silencing , computational biology , biology , small rna , rna induced silencing complex , rna , rna silencing , function (biology) , rna interference , microbiology and biotechnology , cancer research , non coding rna , gene , genetics

Big things come in small packages : MicroRNAs (miRNAs) are small regulatory RNA molecules in eukaryotes. Altered miRNA expression patterns can be used as a diagnostic tool, for example, in patients with chronic lymphatic leukemia. Also, the inhibition of miRNA function in vivo has been recently achieved by using “antagomirs”—antisense cholesterol conjugates (see scheme; miRNP=miRNA–protein complex, RISC=RNA‐induced silencing complex).

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