Synthesis of Triphosphorous Bidentate Phosphine–Phosphoramidite Ligands: Application in the Highly Enantioselective Hydrogenation of  ortho ‐Substituted Aryl Enamides | Zendy

Zhang Weicheng | Zendy; Zhang Xumu | Zendy

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Synthesis of Triphosphorous Bidentate Phosphine–Phosphoramidite Ligands: Application in the Highly Enantioselective Hydrogenation of ortho ‐Substituted Aryl Enamides

Author(s) -

Zhang Weicheng,

Zhang Xumu

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601501

Subject(s) - phosphoramidite , phosphine , denticity , aryl , chemistry , enantioselective synthesis , catalysis , asymmetric hydrogenation , combinatorial chemistry , medicinal chemistry , organic chemistry , crystal structure , dna , biochemistry , alkyl , oligonucleotide

New couple : A novel combination of phosphine and phosphoramidite groups is applied to the preparation of pseudo‐ C 2 ‐symmetric triphosphorous bidentate phosphine–phosphoramidite ligands 1 . Unprecedented enantioselectivities toward ortho ‐substituted aryl enamides and a 1‐naphthylenamide in Rh‐catalyzed hydrogenation reactions are obtained.

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