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Synthesis of Triphosphorous Bidentate Phosphine–Phosphoramidite Ligands: Application in the Highly Enantioselective Hydrogenation of ortho ‐Substituted Aryl Enamides
Author(s) -
Zhang Weicheng,
Zhang Xumu
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601501
Subject(s) - phosphoramidite , phosphine , denticity , aryl , chemistry , enantioselective synthesis , catalysis , asymmetric hydrogenation , combinatorial chemistry , medicinal chemistry , organic chemistry , crystal structure , dna , biochemistry , alkyl , oligonucleotide
New couple : A novel combination of phosphine and phosphoramidite groups is applied to the preparation of pseudo‐ C 2 ‐symmetric triphosphorous bidentate phosphine–phosphoramidite ligands 1 . Unprecedented enantioselectivities toward ortho ‐substituted aryl enamides and a 1‐naphthylenamide in Rh‐catalyzed hydrogenation reactions are obtained.