New News about an Old Drug: Investigations on the Polymorphism of Triamcinolone Acetonide | Zendy

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New News about an Old Drug: Investigations on the Polymorphism of Triamcinolone Acetonide

Author(s) -

Näther Christian,

Jeß Inke

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601468

Subject(s) - triamcinolone acetonide , polymorphism (computer science) , drug , acetonide , chemistry , computer science , pharmacology , medicine , ophthalmology , biochemistry , gene , allele

Even a very old drug holds some surprises when its polymorphism is investigated in detail. The commercially available form of triamcinolone acetonide (modification I ) is a hydrate that contains a small amount of water, which is responsible for its stability. The removal of water results in a transformation into the previously unknown modification II . This finding may have a large impact on the production of the dosage form.

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