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Enamine‐Based Aldol Organocatalysis in Water: Are They Really “All Wet”?
Author(s) -
Brogan Andrew P.,
Dickerson Tobin J.,
Janda Kim D.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601392
Subject(s) - organocatalysis , aldol reaction , enamine , chemistry , aqueous solution , catalysis , organic chemistry , enantioselective synthesis
Reactions with , in , or on water? Despite claims to the contrary, few examples of truly aqueous organocatalysis have been reported. Close examination of the data from recent reports reveals that these reactions likely occur in concentrated organic phases.