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Dinuclear Double‐Stranded Metallosupramolecular Ruthenium Complexes: Potential Anticancer Drugs
Author(s) -
Hotze Anna C. G.,
Kariuki Benson M.,
Han Michael J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601351
Subject(s) - ruthenium , bridge (graph theory) , chemistry , stereochemistry , architecture , twist , computational biology , combinatorial chemistry , computer science , biochemistry , biology , art , mathematics , geometry , catalysis , visual arts , anatomy
Just add a twist : Metallosupramolecular architecture design is used to create anti‐cancer agents with high activities in human breast cancer cell lines. Three isomers, which comprise a nonhelical metallocyclophane, an unsaturated double helicate, and a new type of double helicate, bridge the fields of metallosupramolecular architecture and anticancer drug design (picture: double‐helical trans / cis isomer; red Ru, green Cl).