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The Roles of Hydrogen Bonding and Sterics in RNA Interference
Author(s) -
Somoza Alvaro,
Chelliserrykattil Jijumon,
Kool Eric T.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601311
Subject(s) - rna , rna interference , selectivity , interference (communication) , sequence (biology) , nucleotide , hydrogen bond , steric effects , computational biology , biology , chemistry , genetics , gene , stereochemistry , biochemistry , computer science , telecommunications , molecule , channel (broadcasting) , organic chemistry , catalysis
Better than normal : RNA‐interference studies with mismatched target RNA have demonstrated sequence selectivity (at the single‐nucleotide level) at many different positions of the RNA strand. The use of rF in place of rU at position 7 appears to enhance sequence selectivity beyond that of the natural base.