Premium
Formal Synthesis of (+)‐Catharanthine
Author(s) -
Moisan Lionel,
Thuéry Pierre,
Nicolas Marc,
Doris Eric,
Rousseau Bernard
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601307
Subject(s) - formal synthesis , computer science , key (lock) , natural product , block (permutation group theory) , product (mathematics) , stereochemistry , chemistry , mathematics , operating system , combinatorics , geometry
Madagascan periwinkle is the current source of (+)‐catharanthine, the crucial building block of the major antitumor agent vinorelbine. In the formal synthesis of this natural product, the key intermediate 1 described by Büchi and co‐workers was obtained in virtually optically pure form from L ‐serine. The strategy presented may be viewed as a general synthetic approach to optically active isoquinuclidines.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom