Premium
Efforts towards Expansion of the Genetic Alphabet: Pyridone and Methyl Pyridone Nucleobases
Author(s) -
Leconte Aaron M.,
Matsuda Shigeo,
Hwang Gil Tae,
Romesberg Floyd E.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601272
Subject(s) - alphabet , nucleobase , computer science , extension (predicate logic) , base (topology) , information retrieval , dna , genetics , biology , mathematics , programming language , philosophy , linguistics , mathematical analysis
Getting on with it : A common problem with hydrophobic non‐natural base pairs—the inefficient extension following such a base pair—is reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem of non‐natural bases: mispairs with deoxyadenosine.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom