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Total Synthesis of Tubulysin U and V
Author(s) -
Dömling Alexander,
Beck Barbara,
Eichelberger Uwe,
Sakamuri Sukumar,
Me Sanjay,
Chen QuinZene,
Lu Yingchun,
Wessjohann Ludger A.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601259
Subject(s) - total synthesis , thiazole , computer science , stereochemistry , chemistry , combinatorial chemistry , scheme (mathematics) , mathematics , mathematical analysis
Multicomponent method : Tubulysins are among the most potent cytotoxic agents known. Now the first total synthesis of some members has been achieved by utilizing a rapid three‐component reaction for the synthesis of the unusual central thiazole amino acid tubuvaline (see scheme; Boc= tert ‐butoxycarbonyl, Ac=acetyl), thereby opening new perspectives for anticancer drug development.