Total Synthesis of Tubulysin U and V | Zendy

Dömling Alexander | Zendy; Beck Barbara | Zendy; Eichelberger Uwe | Zendy; Sakamuri Sukumar | Zendy; Me Sanjay | Zendy; Chen QuinZene | Zendy; Lu Yingchun | Zendy; Wessjohann Ludger A. | Zendy

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Total Synthesis of Tubulysin U and V

Author(s) -

Dömling Alexander,

Beck Barbara,

Eichelberger Uwe,

Sakamuri Sukumar,

Me Sanjay,

Chen QuinZene,

Lu Yingchun,

Wessjohann Ludger A.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601259

Subject(s) - total synthesis , thiazole , computer science , stereochemistry , chemistry , combinatorial chemistry , scheme (mathematics) , mathematics , mathematical analysis

Multicomponent method : Tubulysins are among the most potent cytotoxic agents known. Now the first total synthesis of some members has been achieved by utilizing a rapid three‐component reaction for the synthesis of the unusual central thiazole amino acid tubuvaline (see scheme; Boc= tert ‐butoxycarbonyl, Ac=acetyl), thereby opening new perspectives for anticancer drug development.

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