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Significantly Improved Method for the Pd‐Catalyzed Coupling of Phenols with Aryl Halides: Understanding Ligand Effects
Author(s) -
Burgos Carlos H.,
Barder Timothy E.,
Huang Xiaohua,
Buchwald Stephen L.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601253
Subject(s) - halide , aryl , phenols , catalysis , ligand (biochemistry) , chemistry , combinatorial chemistry , organic chemistry , coupling (piping) , materials science , biochemistry , alkyl , receptor , metallurgy
A variety of diaryl ethers were synthesized by the Pd‐catalyzed reaction of (hetero)aryl halides and phenols. These reactions were achieved through the use of two new di‐ tert ‐butylphosphino biaryl ligands that overcome several limitations of previously described methods.