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Gold(I)‐Catalyzed Reaction of 1‐(1‐Alkynyl)‐cyclopropyl Ketones with Nucleophiles: A Modular Entry to Highly Substituted Furans
Author(s) -
Zhang Junliang,
Schmalz HansGünther
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601252
Subject(s) - nucleophile , catalysis , chemistry , ring (chemistry) , modular design , combinatorial chemistry , medicinal chemistry , atom (system on chip) , organic chemistry , computer science , programming language , parallel computing
Ring round : 1‐Acyl‐1‐alkynyl‐cyclopropanes smoothly react with nucleophiles in the presence of a gold(I) catalyst to afford substituted furans in a fully atom‐economical fashion (see scheme; Nu=nucleophile, Tf=trifluoromethanesulfonyl). The reaction tolerates a wide range of substrates.