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Water‐Soluble Dendrimeric Two‐Photon Tracers for In Vivo Imaging
Author(s) -
Krishna Thatavarathy R.,
Parent Manuel,
Werts Martinus H. V.,
Moreaux Laurent,
Gmouh Said,
Charpak Serge,
Caminade AnneMarie,
Majoral JeanPierre,
BlanchardDesce Mireille
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601246
Subject(s) - fluorophore , two photon excitation microscopy , in vivo , covalent bond , biocompatible material , preclinical imaging , materials science , nanotechnology , chemistry , fluorescence , optics , biomedical engineering , physics , medicine , organic chemistry , microbiology and biotechnology , biology
In a (nut)shell : Covalently wrapped in a protecting and solubilizing dendrimeric shell (see picture), an initially hydrophobic two‐photon fluorophore becomes a biocompatible contrast agent with strong emission for imaging in vivo by multiphoton microscopy.