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Microsphere‐Based Real‐Time Calcium Sensing
Author(s) -
SánchezMartín Rosario M.,
Cuttle Matt,
Mittoo Stifun,
Bradley Mark
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601242
Subject(s) - microsphere , calcium , fluorescence , ion , covalent bond , computer science , chemistry , nanotechnology , materials science , chemical engineering , physics , engineering , optics , organic chemistry
Sensing within the cell : Microspheres (2 μm) covalently loaded with calcium sensors can be delivered efficiently into living cells to analyze the intracellular changes in the concentration of Ca 2+ ions in real time. The figure shows the real‐time ratiometric fluorescent analysis (400/475 nm ratio) of the release of Ca 2+ ions in cells loaded with the microspheres.
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