A Population of Thermostable Reverse Transcriptases Evolved from  Thermus aquaticus  DNA Polymerase I by Phage Display | Zendy

VichierGuerre Sophie | Zendy; Ferris Stéphane | Zendy; Auberger Nicolas | Zendy; Mahiddine Karim | Zendy; Jestin JeanLuc | Zendy

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A Population of Thermostable Reverse Transcriptases Evolved from Thermus aquaticus DNA Polymerase I by Phage Display

Author(s) -

VichierGuerre Sophie,

Ferris Stéphane,

Auberger Nicolas,

Mahiddine Karim,

Jestin JeanLuc

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601217

Subject(s) - thermus aquaticus , reverse transcriptase , dna polymerase , polymerase , population , biology , dna , enzyme , phage display , genetics , microbiology and biotechnology , computational biology , polymerase chain reaction , gene , biochemistry , demography , sociology , antibody

Running in reverse : A set of enzymes selected according to their RNA‐dependent DNA polymerase activity from a library of more than 10 7 mutant enzymes has been characterized. The product was specifically bound to catalytically active proteins displayed on filamentous bacteriophage. The selected variants have a catalytic efficiency for reverse transcription that is two orders of magnitude higher.

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