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Mismatch‐Binding Ligands Function as a Molecular Glue for DNA
Author(s) -
Peng Tao,
Dohno Chikara,
Nakatani Kazuhiko
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601190
Subject(s) - dimer , dna , glue , sequence (biology) , chemistry , biophysics , function (biology) , stereochemistry , crystallography , biology , biochemistry , genetics , materials science , organic chemistry , composite material
A sticky end : Two DNA strands that produce three contiguous mismatches (5′‐TGG‐3′/5′‐TGG‐3′ sequence) do not hybridize spontaneously, but are adhered by the mismatch‐binding ligand naphthyridine carbamate dimer ( NC ; see picture, red rectangles: naphthyridine rings).