Ruthenium‐Catalyzed Propargylic Reduction of Propargylic Alcohols with Silanes | Zendy

Nishibayashi Yoshiaki | Zendy; Shinoda Akira | Zendy; Miyake Yoshihiro | Zendy; Matsuzawa Hiroshi | Zendy; Sato Mitsunobu | Zendy

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Ruthenium‐Catalyzed Propargylic Reduction of Propargylic Alcohols with Silanes

Author(s) -

Nishibayashi Yoshiaki,

Shinoda Akira,

Miyake Yoshihiro,

Matsuzawa Hiroshi,

Sato Mitsunobu

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601181

Subject(s) - triethylsilane , silanes , hydrosilylation , chemistry , moiety , catalysis , ruthenium , selectivity , hydride , medicinal chemistry , organic chemistry , silane , combinatorial chemistry , metal

Ru 2 can do it! Substitution of the OH moiety in propargylic alcohols by hydride proceeds smoothly with triethylsilane by catalysis with the thiolate‐bridged diruthenium complex 1 (see scheme; Cp*=η 5 ‐C 5 Me 5 ). This reaction gives the corresponding alkynes in good to high yields with complete selectivity, in contrast to a monoruthenium‐catalyzed hydrosilylation of propargylic alcohols with silanes.

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