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Tuning Linear Copolymers into Protein‐Specific Hosts
Author(s) -
Koch Sebastian J.,
Renner Christian,
Xie Xiulan,
Schrader Thomas
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601161
Subject(s) - copolymer , isoelectric point , lysozyme , monomer , stoichiometry , chemistry , polymer , polymer chemistry , biochemistry , enzyme , organic chemistry
Being picky : A new concept for selective protein recognition by artificial receptor molecules involves statistical copolymerization of simple binding monomers in defined stoichiometric ratios. As an example of its efficiency, an arginine‐rich lysozyme is recognized by a bisphosphonate‐rich copolymer with a remarkable K d value of 25 n M , 100‐times superior to that of cytochrome c, which is comparable in size and isoelectric point.