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Efficient Polymer‐Assisted Strategy for the Deprotection of Protected Oligosaccharides
Author(s) -
Tanaka Hiroshi,
Ishida Tadasuke,
Matoba Nobuatsu,
Tsukamoto Hirokazu,
Yamada Haruo,
Takahashi Takashi
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601128
Subject(s) - trifluoroacetic acid , moiety , sugar , linker , chemistry , cleavage (geology) , protecting group , combinatorial chemistry , organic chemistry , computer science , biology , programming language , alkyl , fracture (geology) , paleontology
New strategies in sugar synthesis : A prelinker containing a dihydropyranyl moiety and an activated ester can be attached to a sugar, which is then loaded onto an amino‐modified support by amidation. Standard protecting‐group manipulations are possible. Final cleavage of the linker under mildly acidic conditions provides the fully deprotected oligosaccharides. TFA=trifluoroacetic acid.