Supramolecular Control of Oligosaccharide–Protein Interactions: Switchable and Tunable Ligands for Concanavalin A Based on β‐Cyclodextrin | Zendy

Smiljanic Nicolas | Zendy; Moreau Vincent | Zendy; Yockot Duplex | Zendy; Benito Juan M. | Zendy; García Fernández José M. | Zendy; DjedaïniPilard Florence | Zendy

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Supramolecular Control of Oligosaccharide–Protein Interactions: Switchable and Tunable Ligands for Concanavalin A Based on β‐Cyclodextrin

Author(s) -

Smiljanic Nicolas,

Moreau Vincent,

Yockot Duplex,

Benito Juan M.,

García Fernández José M.,

DjedaïniPilard Florence

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200601123

Subject(s) - supramolecular chemistry , allosteric regulation , chemistry , cyclodextrin , lectin , oligosaccharide , effector , inclusion (mineral) , concanavalin a , stereochemistry , molecule , biochemistry , receptor , organic chemistry , in vitro , mineralogy

The ins and outs of binding : Supramolecular control of carbohydrate–protein interactions has been achieved through the design of β‐cyclodextrin (βCD) based conjugates whose conformation is dependent on a reversible self‐inclusion process. The accessibility of glycoligands to the lectin binding site is then regulated by allosteric inclusion of effector/antagonist‐like molecules in the βCD cavity (see scheme).

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