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Supramolecular Control of Oligosaccharide–Protein Interactions: Switchable and Tunable Ligands for Concanavalin A Based on β‐Cyclodextrin
Author(s) -
Smiljanic Nicolas,
Moreau Vincent,
Yockot Duplex,
Benito Juan M.,
García Fernández José M.,
DjedaïniPilard Florence
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601123
Subject(s) - supramolecular chemistry , allosteric regulation , chemistry , cyclodextrin , lectin , oligosaccharide , effector , inclusion (mineral) , concanavalin a , stereochemistry , molecule , biochemistry , receptor , organic chemistry , in vitro , mineralogy
The ins and outs of binding : Supramolecular control of carbohydrate–protein interactions has been achieved through the design of β‐cyclodextrin (βCD) based conjugates whose conformation is dependent on a reversible self‐inclusion process. The accessibility of glycoligands to the lectin binding site is then regulated by allosteric inclusion of effector/antagonist‐like molecules in the βCD cavity (see scheme).