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Sequence‐Dependent Stereoselectivity in the Binding of Tetrapeptides in Water by a Flexible Artificial Receptor
Author(s) -
Schmuck Carsten,
Wich Peter
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601046
Subject(s) - tetrapeptide , stereoselectivity , sequence (biology) , chemistry , stereochemistry , receptor , peptide , combinatorial chemistry , biochemistry , catalysis
All in a row : The screening of a combinatorial library with 320 substrates shows that an artificial triscationic receptor efficiently binds anionic tetrapeptides in water with association constants up to K a =27 000 M −1 . Moreover, the receptor shows a remarkable sequence‐dependent stereoselectivity between D ‐Ala and l‐ Ala in certain positions of the tetrapeptide.
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