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Multiple Palladium‐Catalyzed Reactions for the Synthesis of Analogues of the Highly Potent Insecticide Spinosyn A
Author(s) -
Tietze Lutz F.,
Brasche Gordon,
Stadler Christian,
Grube Alexander,
Böhnke Niels
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200601003
Subject(s) - palladium , chemistry , combinatorial chemistry , catalysis , heck reaction , stereochemistry , organic chemistry
Resistance is useless? The increasing resistance towards (−)‐spinosyns A ( 1 ) and D ( 2 ) used as plant‐protection agents makes new derivatives of these natural products necessary. On the basis of investigations into the structure–activity relationships a convergent approach to the synthesis of novel spinosyn A analogues ( 3 ) is developed. A double Heck reaction is the key step in the construction of the basic carbocyclic framework.