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Lipid‐Anchored Oligonucleotides for Stable Double‐Helix Formation in Distinct Membrane Domains
Author(s) -
Kurz Anke,
Bunge Andreas,
Windeck AnneKatrin,
Rost Maximilian,
Flasche Wolfgang,
Arbuzova Anna,
Strohbach Denise,
Müller Sabine,
Liebscher Jürgen,
Huster Daniel,
Herrmann Andreas
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600822
Subject(s) - oligonucleotide , nucleotide , dna , triple helix , membrane , helix (gastropod) , chemistry , biophysics , base pair , biochemistry , stereochemistry , crystallography , biology , gene , ecology , snail
Anchoring for DNA : A lipophilic oligonucleotide consisting of 21 thymidine units and two lipophilic nucleotides L was synthesized and bound to vesicular surfaces (see fluorescence image). The membrane‐bound oligonucleotide binds complementary DNA strands by formation of Watson–Crick base pairs. The lipid‐anchored oligonucleotide is preferentially enriched in liquid‐disordered membrane domains.