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The Heck Reaction of Electron‐Rich Olefins with Regiocontrol by Hydrogen‐Bond Donors
Author(s) -
Mo Jun,
Xiao Jianliang
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600799
No salt please : Halide scavengers AgOTf and TlOAc are not required for the Heck coupling of electron‐rich olefins with aryl bromides and chlorides. Using ammonium additives, these reactions can be carried out in either an imidazolium ionic liquid or a common molecular solvent, thus furnishing 1,1′‐disubstituted olefins in high yields with excellent regioselectivities.