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18 F‐Labeling of Peptides by means of an Organosilicon‐Based Fluoride Acceptor
Author(s) -
Schirrmacher Ralf,
Bradtmöller Gerrit,
Schirrmacher Esther,
Thews Oliver,
Tillmanns Julia,
Siessmeier Thomas,
Buchholz Hans G.,
Bartenstein Peter,
Wängler Björn,
Niemeyer Christof M.,
Jurkschat Klaus
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600795
Subject(s) - organosilicon , chemistry , acceptor , fluoride , content (measure theory) , combinatorial chemistry , computer science , radiochemistry , organic chemistry , mathematics , physics , inorganic chemistry , mathematical analysis , condensed matter physics
F on : Fluorotriorganosilyl‐derivatized Tyr 3 ‐octreotate was labeled with 18 F − providing the first practical formulation in 18 F‐radiochemistry for the labeling of a peptide (see scheme). The very mild reaction conditions and the fast labeling make this strategy a valuable tool for the synthesis of 18 F‐radiopharmaceuticals.