18 F‐Labeling of Peptides by means of an Organosilicon‐Based Fluoride Acceptor | Zendy

Schirrmacher Ralf | Zendy; Bradtmöller Gerrit | Zendy; Schirrmacher Esther | Zendy; Thews Oliver | Zendy; Tillmanns Julia | Zendy; Siessmeier Thomas | Zendy; Buchholz Hans G. | Zendy; Bartenstein Peter | Zendy; Wängler Björn | Zendy; Niemeyer Christof M. | Zendy; Jurkschat Klaus | Zendy

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18 F‐Labeling of Peptides by means of an Organosilicon‐Based Fluoride Acceptor

Author(s) -

Schirrmacher Ralf,

Bradtmöller Gerrit,

Schirrmacher Esther,

Thews Oliver,

Tillmanns Julia,

Siessmeier Thomas,

Buchholz Hans G.,

Bartenstein Peter,

Wängler Björn,

Niemeyer Christof M.,

Jurkschat Klaus

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200600795

Subject(s) - organosilicon , chemistry , acceptor , fluoride , content (measure theory) , combinatorial chemistry , computer science , radiochemistry , organic chemistry , mathematics , physics , inorganic chemistry , mathematical analysis , condensed matter physics

F on : Fluorotriorganosilyl‐derivatized Tyr 3 ‐octreotate was labeled with 18 F − providing the first practical formulation in 18 F‐radiochemistry for the labeling of a peptide (see scheme). The very mild reaction conditions and the fast labeling make this strategy a valuable tool for the synthesis of 18 F‐radiopharmaceuticals.

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