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Selective Construction of Carbocyclic Eight‐Membered Rings by Ring‐Closing Metathesis of Acyclic Precursors
Author(s) -
Michaut Antoine,
Rodriguez Jean
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600787
Subject(s) - ring closing metathesis , metathesis , ring (chemistry) , reagent , salt metathesis reaction , closing (real estate) , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , business , polymerization , polymer , finance
Although the efficient preparation of cyclooctanoids has remained a long‐standing objective, a real breakthrough was possible only relatively recently with the development of more specific reagents and by the development of new reactions. The direct construction of carbocyclic eight‐membered rings from acyclic precursors is still a challenge, mainly because of unfavorable entropic and enthalpic factors that preclude ring formation. This Minireview describes the utilization of ring‐closing metathesis (RCM) as a new approach to synthesize cyclooctanoids.