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Constraints on the Structure of (CUG) 97 RNA from Magic‐Angle‐Spinning Solid‐State NMR Spectroscopy
Author(s) -
Riedel Kerstin,
Herbst Christian,
Häfner Sabine,
Leppert Jörg,
Ohlenschläger Oliver,
Swanson Maurice S.,
Görlach Matthias,
Ramachandran Ramadurai
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600769
Subject(s) - magic angle spinning , rna , solid state nuclear magnetic resonance , glycosidic bond , nuclear magnetic resonance spectroscopy , spinning , crystallography , chemistry , spectroscopy , solid state , helix (gastropod) , dihedral angle , materials science , stereochemistry , physics , nuclear magnetic resonance , molecule , hydrogen bond , polymer chemistry , biochemistry , biology , organic chemistry , ecology , quantum mechanics , snail , gene , enzyme
Twists in a spin : RNA structural constraints have been obtained directly by exploiting the dependence of inter‐ and intranucleotide 1 H– 1 H interactions on RNA conformation through the use of 13 C MAS solid‐state NMR spectroscopy. The data provide evidence that (CUG) 97 RNA principally adopts an A‐form helix conformation with a C3′‐ endo sugar pucker and an anti glycosidic torsion angle χ (see model).
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