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Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins
Author(s) -
Bang Duhee,
Pentelute Brad L.,
Kent Stephen B. H.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600702
Subject(s) - ligation , native chemical ligation , thioester , key (lock) , peptide , chemistry , computer science , chemical ligation , combinatorial chemistry , convergent synthesis , computational biology , information retrieval , chemical synthesis , biochemistry , biology , microbiology and biotechnology , in vitro , enzyme , computer security
Converging on the goal : New chemistry enables the key Cys‐peptide‐( α thioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.